3 edition of senescence-accelerated mouse (SAM) found in the catalog.
senescence-accelerated mouse (SAM)
International Conference on Senescence (2nd 2003 Sapporo-shi, Japan).
Includes bibliographical references and index.
|Statement||editor-in-chief, Yasuyuki Nomura ; editors, Toshio Takeda, Yasunobu Okuma.|
|Series||International congress series -- no. 1260|
|Contributions||Nomura, Yasuyuki, Ph.D., Takeda, Toshio, 1931-, Okuma, Yasunobu, Ph.D.|
|LC Classifications||QP86 .I579 2003|
|The Physical Object|
|Pagination||xv, 448 p. :|
|Number of Pages||448|
The senescence-accelerated mouse prone 8 (SAMP8) is mouse line that displays a phenotype of accelerated aging. It shows degrees of activity loss, hair loss, lordokyphosis and early death. The SAMP8 mouse, was derived from the SAM-P/2 line by Japanese Professor, Toshio Takeda as a rapidly aging dementia mouse : Zhengcai Du, Fangcao Fanshi, Yu-Heng Lai, Jung-Ren Chen, Erwei Hao, Jiagang Deng, Chung-Der Hsiao. Senescence-accelerated mouse prone 8 (SAMP8), a non‑transgenic animal model used for researching sporadic Alzheimer's disease (AD), presents AD pathologies and overall dysregulation in brain.
Probiotic supplements are potential therapeutic agents for age-related disorders due to their antioxidant and anti-inflammatory properties. However, the effect of probiotics on age-related brain dysfunction remains unclear. To investigate the effects of Lactobacillus paracasei PS23 (LPPS23) on the progression of age-related cognitive decline, male and female senescence-accelerated mouse Cited by: 5. Sesame lignans, which are biologically active compounds present in sesame seeds and oil, are known to have neuroprotective effects in several models of brain dysfunction. However, the effects of sesame lignans on age-related brain dysfunction are not clear and were thus investigated in the present study using a senescence-accelerated mouse (SAMP10). Two Author: Satomi Shimoyoshi, Daisuke Takemoto, Yoshiko Ono, Yoshinori Kitagawa, Hiroshi Shibata, Susumu Tomono.
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This volume represents a summary of reports on studies using the Senescence Accelerated Mouse, as presented at the 2nd International Conference on Senescence: The SAM Model, held from July in Senescence-accelerated mouse book, Japan. This volume represents a summary of reports on studies using the Senescence Accelerated Mouse, as presented at the 2nd International Conference on Senescence: The SAM Model, held from July in Sapporo, Japan.
Work on the SAM began in in the Department of Pathology, Chart Disease Research Institute (currently Field of Regeneration Control Institute. The Senescence-Accelerated Mouse (SAM) has been under development by our research team at Kyoto University since through the selective inbreeding of the AKR/J strain of mice donated try the Jackson Laboratory inbased on a graded score for senescence, life span, and pathologic by: D.A.
Butterfield, H.F. PoonThe senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's diseaseCited by: Mouse Models of Accelerated Cellular Senescence: Methods and Protocols.
Mouse Models of Accelerated Cellular Senescence. Ensure that the tail of the mouse. The Senescence Accelerated Mouse-Prone 8 (SAMP8) is a naturally occuring mouse line that displays a phenotype of accelerated aging. While maintaining an inbred AKR/J line in the early 's, researchers at Kyoto University became aware that some of the progeny exhibited a moderate to severe degree of activity loss, hair loss, lordokyphosis and early death.
The Senescence-Accelerated Mouse (SAM) represents a group of inbred mouse strains developed by Toshio Takeda and his colleagues at Kyoto University as a model for the study of human aging and age-related by: The rare inbred mouse strains generated by careful breeding and selection known as the senescence-accelerated prone mice afforded us the opportunity to study a complex cascade that ultimately leads to progressive neurological decline during the aging by: Five litters with severe senescence were selected to further propagate and examine these characteristics.
Litters that showed normal aging were selected as a senescence-resistant series (R-series). The genetic background of the SAM mice became suspect after the pathological ﬁndings were different from the AKR/J mouse. The life span in the P series was shortened by about 26% of that of the R series.
In view of the evidence obtained from the survivors, the growth rate and Gompertz function, the aging pattern in the P series was considered to be an acceleration of senescence. The P series has been named "SAM" ("Senescence Accelerated Mouse").Cited by: D.
Butterfield and H. Poon, “The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease,” Experimental Gerontology, vol. 40, Cited by: The senescence-accelerated mouse (SAM) is an accelerated aging model that was established through phenotypic selection from a common genetic pool of AKR/J strain of mice.
The SAM model was established inincluding nine major senescence-accelerated mouse prone (SAMP) substrains and three major senescence-accelerated mouse resistant (SAMR) Cited by: To do so, a useful animal model of age-associated diseases is essential.
As one alternative model, Takeda et al. (1,2) developed the senescence-accelerated mouse (SAM) as a murine model of accelerated aging. SAM strains have a shortened life-span and develop early manifestations of senescence, including decreased activity, alopecia, lack of Author: Yasuyuki Nomura, Yasunobu Okuma, Yoshihisa Kitamura.
The Senescence Accelerated Mouse. The Senescence Accelerated Mouse (SAM) strains of mice were developed by Toshio Takeda at the Chest Disease Research Institute, Kyoto University, as the result of an accidental outcrossing of AKR/J mice and another unknown albino mouse strain in After receiving several pairs of AKR/J mice Takeda began.
The senescence-accelerated mouse (SAM) was developed by selective breeding of the AKR/J strain, based on a graded score for senescence, which led to the development of both senescence-accelerated. The senescence-accelerated mouse strain SAMP8 was proposed as a valuable animal model for the study of liver diseases.
To gain a better understanding of the mechanisms underlying degenerative processes in SAMP8 mice livers, we studied the oxidative-induced damage in 5-month-old SAMP8 mice and SAMR1, senescence-accelerated-resistant by: The classic model of senescence acceleration and age-associated disorders is the “ senescence accelerated mouse ” (SAM) mouse, originally developed by Takeda et al.
in Japan. 99 A total of nine strains of accelerated aging were identified, out of which the SAMP6 strain was established as a model for senile osteoporosis characterized by low peak bone mass at their maturation.
99 The low bone mass in these mice. The senescence-accelerated mouse (SAM) strains were developed at Kyoto University from a colony of AKR/J mice that were selectively bred based on senescence, life span and pathologic phenotypes and were generously provided to our laboratory [18, 20, 59].
Founder mating pairs of S8/Ta (F), S10//Ta (F) and SR1TA (F) mice raised under. The senescence-accelerated mouse (SAM), a murine model of accelerated senescence, was established by Takeda et al. Among SAM strains, SAMP10 shows impaired learning at the age of 10–12 months with age-related brain atrophy [ 13, 14 ] and behavioral depression [ 15, 16 ], which are thought to be caused by reactive oxygen species (ROS).Author: Satomi Shimoyoshi, Daisuke Takemoto, Yoshiko Ono, Yoshinori Kitagawa, Hiroshi Shibata, Susumu Tomono.
Aging is a predominant risk factor for the development and progression of cardiovascular complications. Physiologically and anatomically, the heart undergoes numerous changes that result in poor cardiac function in the elderly population. Recently, several studies have provided promising results, confirming the ability of the senescence-accelerated mouse-prone 8 Author: Vijayasree V.
Giridharan, Vijayasree V. Giridharan, Vengadeshprabhu Karupppagounder, Vengadeshprabhu. Senescence-accelerated mouse (SAM) is a series of inbred mouse strains that includes SAMP1, SAMP6, SAMP8, SAMP10, and SAMR1.
SAMP strains .The Senescence-Accelerated Mouse (SAM) Development of the SAM strain (Senescence-Accelerated Mouse) The SAM strain of mice has been derived from AKR/J strain which were donated by the Jackson Laboratory (Bar Harbor, Maine, USA) and maintained in our laboratory.The senescence-accelerated mouse 8 (SAM-8) is a commonly used animal model for aging, which is characterized with a significantly shortened life span compared to that of SAM-R1 mouse .